The COVID-19 Therapeutics Accelerator is funding clinical trials that will answer whether the anti-malarial drugs hydroxychloroquine and chloroquine can be used to prevent the spread of COVID-19.

As the new coronavirus continues to spread across the world, we are still no closer to knowing what drugs or therapies will stop it.

There has been considerable hype around the potential of hydroxychloroquine and chloroquine to stop the spread of COVID-19. While some have described these drugs as possible game-changers, others have reported serious concerns(opens in a new tab).

Investing in research at scale and at speed is the only way to find out definitively whether these drugs can help in this pandemic. That’s why, as part of the COVID-19 Therapeutics Accelerator, an initiative launched by Wellcome, the Bill & Melinda Gates Foundation and Mastercard, we’re investing £7.5 million in hydroxychloroquine and chloroquine clinical trials.

What these trials will look at?

The clinical trials will run in countries across the world from April. They will investigate whether hydroxychloroquine and chloroquine can be used safely to prevent the spread of disease in people who have been exposed, or are at high risk of exposure, to the coronavirus. The trials will involve healthcare workers at the front line, as well as people with no symptoms who have had close contact with someone confirmed or suspected of having COVID-19.

Equitable access lies at the heart of the COVID-19 Therapeutics Accelerator. So research findings will be open access to ensure researchers, policy makers and global health leaders everywhere can use the work. The COVID-19 Therapeutics Accelerator will also help to ensure that effective products are affordable and made available to all, especially those in low-resource settings.

Both drugs are cheap to make and can be manufactured quickly in volume. If these trials prove hydroxychloroquine and chloroquine to be effective, the drugs could be rapidly rolled out across the world to slow this pandemic.

If they help us reduce the amount of time people spend in hospital, it will have a big impact – health professionals will be able to return to work and people home to their families sooner.

What do we know about hydroxychloroquine and chloroquine?
Hydroxychloroquine and chloroquine have been approved as safe and effective drugs to treat malaria. When taken, they accumulate in lung tissue where the coronavirus is found – this is why researchers think they might be effective against the virus.

There’s enough early laboratory and anecdotal evidence to get some researchers excited. None of that evidence is rigorous or definitive though. No large-scale clinical trials on the use of these drugs for COVID-19 have taken place in humans to date.

The World Health Organization (WHO) is also running its own ‘megatrial’ of chloroquine(opens in a new tab) alongside other potential therapies. The researchers working on the COVID-19 Therapeutics Accelerator trials are collaborating closely with the WHO to share data and ensure the knowledge generated can benefit people as quickly as possible.

By Nick Cammack

The Express News


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